HIGHLIGHTS
- Pancreaticoduodenectomy (PD) is a complex surgical procedure with significant morbidity.
- Associated sarcopenia could be potential risk for increased post operative complications.
- Comprehensive assessment of sarcopenia is an essential tool to predict post operative complication after PD.
ABSTRACT
Background – Pancreaticoduodenectomy (PD) is a complex procedure with significant postoperative morbidity. Associated sarcopenia could be a potential risk for increased post-operative complications. Methods – Patients who had undergone pancreaticoduodenectomy between July 2019 to December 2020 were included in the study. Preoperative comprehensive sarcopenia assessment was done by hand grip strength test, Dual energy X-ray absorptiometry (DEXA) scan and gait speed test. Only myopenia was also assessed by DEXA scan in all the patients. Post-operative outcomes were recorded and the association of preoperative sarcopenia with postoperative complications were analyzed. Results – Of 47 patients assessed, 36 patients were finally included (Median age -58 years (IQR-51,68) years,26 male). The five (13.8%) had sarcopenia confirmed on comprehensive assessment. Thirteen (36.5%) patients had myopenia on DEXA assessment. The major Clavien-Dindo complications were significantly higher in sarcopenia (40% vs 6.6%, P=0.04) and similarly, grade C DGE (40% vs 0, P=0.04) was also more frequent in patients with sarcopenia. The patients with myopenia only did not have a significant correlation with post-operative complications. (15.4% vs 8.7% P=0.66). Conclusion – Comprehensive assessment using muscle strength and muscle quantity is essential for sarcopenia diagnosis. Preoperative sarcopenia is a significant risk factor for post-operative complications.
AUTORES
Saurabh MESHRAM¹, Santosh IRRINKI¹, Vishal SHARMA², Pankaj GUPTA³, Vikas GUPTA⁴, Thakur Deen YADAV⁴, Rajesh GUPTA⁴ and Harjeet SINGH⁴
