HIGHLIGHTS
- Bacterial infections are a frequent complication of cirrhosis and were associated with ascites, hepatic encephalopathy and a high MELD score.
- The most frequent type of infection in this study was spontaneous bacterial peritonitis followed by urinary tract infection.
ABSTRACT
Objectives – to determine the prevalence and identify the factors associated with bacterial infection in cirrhotic patients in Togo. Methods – This was a descriptive and analytical cross-sectional study, with retrospective data collection, conducted in the hepato-gastroenterology department of the Campus University Hospital during three years. All patients hospitalized in the department during this period and diagnosed with cirrhosis were included in the study. Results – During the study period, 270 patients were hospitalized for cirrhosis including 63 cases of bacterial infection, a prevalence of 23.3%. Bacterial infections were represented by spontaneous infection of ascites fluid (15.9%) followed by urinary tract infection (4%). The median length of hospital stay was 10 days Thirty-six of the patients with infection died in hospital, corresponding to a mortality rate of 57.1%. Factors associated with bacterial infection were ascites (P=0.017; OR=4.56), hepatic encephalopathy (P=0.02; OR=4.32), a prothrombin level below 25% (P=0.002; OR=9.67) and a high MELD score (P=0.03; OR=0.93). Conclusion – Bacterial infection occurs in advanced cirrhosis and is associated with a poor prognosis.
AUTORES
Laté Mawuli LAWSON-ANANISSOH, Mawunyo Henoc GBOLOU, Debehoma Venceslas REDAH, Lidawu Roland-Moise KOGOE, Yendoukoa Yves KANAKE and Aklesso BAGNY
